serotonin syndrome as a result of the simultaneous administration of L-tryptophan and tramadol
Co Treatment with the centrally acting analgesic tramadol and L-tryptophan can cause serious side effects. For example, patients who have taken because of strong pain tramadol, may lead to the taking of 1 g L-tryptophan in a distance of several hours to a serotonin syndrome. The serotonin syndrome is usually the result of a greatly increased serotonin activity. In this case, symptoms, such as changes in mental state, restlessness, rapid involuntary muscle twitching, increased reflex readiness, sweating, chills and tremors on. In many cases, these symptoms resolve within a few hours back in full.
Literature:
Houlihan, DJ. Serotonin Syndrome Resulting form co-administration of Tramadol, Venlafaxine, and Mirtazapine.Annals of Pharmacotherapy 2009; 38 (3) :411-413
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