Therapeutic effects of tryptophan
tryptophan is currently approved in Germany as a drug for the treatment of sleep disorders. L-tryptophan is a non-prescription medicine and is offered a dose of 500 mg per tablet (eg L-tryptophan ratiopharm). In the scientific literature that has always stood another application in focus: the treatment of depressive disorders. As an important precursor to the formation of serotonin (5-hydroxytryptamine) may intervene Tryp directly in the metabolism of this vital neurotransmitter.
The influence of the serotonin system to the chemical class of selective serotonin reuptake inhibitors (SSRIs) has in the past 20 years as the most effective therapeutic option for the treatment of depression emerged (Petersen et al. 2002). Besides the influence of depressive symptoms has the Tryp-handed to be effective in reducing interference of affectivity, in particular for the treatment of severe impulsivity proved (aan Rot et al het. 2006).
When seasonal affective disorder (SAD), the so-called winter depression, is deteriorating because of the shortened days with the absence of daylight influence the mood of sensitive people. Besides the well-documented effectiveness in its light therapy (10,000 lux for at least 30 min) also seems to Tryp administration to have an additional positive effect (Lam et al. 1997). Moreover there are indications that a Tryp-dose positive effect on cognitive abilities (Haider et al. 2006).
A major difference compared to the Tryp as a standard of care for depressive disorders apply serotonin reuptake inhibitors is the time to onset. While the Tryp-effect detectable on the symptoms is usually after about a week (. Levitan et al 2000), the serotonin reuptake inhibitors require significantly longer (2-3 weeks) report to the patient about an improvement in symptoms. Moreover there are indications that can enhance the effect of serotonin reuptake inhibitors by the addition of Tryp (Lowe et al. 2006, Levitan et al. 2000).
The influence of the serotonin system to the chemical class of selective serotonin reuptake inhibitors (SSRIs) has in the past 20 years as the most effective therapeutic option for the treatment of depression emerged (Petersen et al. 2002). Besides the influence of depressive symptoms has the Tryp-handed to be effective in reducing interference of affectivity, in particular for the treatment of severe impulsivity proved (aan Rot et al het. 2006).
When seasonal affective disorder (SAD), the so-called winter depression, is deteriorating because of the shortened days with the absence of daylight influence the mood of sensitive people. Besides the well-documented effectiveness in its light therapy (10,000 lux for at least 30 min) also seems to Tryp administration to have an additional positive effect (Lam et al. 1997). Moreover there are indications that a Tryp-dose positive effect on cognitive abilities (Haider et al. 2006).
A major difference compared to the Tryp as a standard of care for depressive disorders apply serotonin reuptake inhibitors is the time to onset. While the Tryp-effect detectable on the symptoms is usually after about a week (. Levitan et al 2000), the serotonin reuptake inhibitors require significantly longer (2-3 weeks) report to the patient about an improvement in symptoms. Moreover there are indications that can enhance the effect of serotonin reuptake inhibitors by the addition of Tryp (Lowe et al. 2006, Levitan et al. 2000).
Under what doses of tryptophan, a sufficient therapeutic effect can be expected?
The assessed as safe and effective dose range of tryptophan with 0.4 to 4 g daily given (Monographie L-tryptophan). In numerous studies on the treatment of depression with tryptophan doses were administered daily 6 g (Herrington et al. In 1974, D'Elia et al. 1977, Steinberg et al. 1999). As a complementary therapy Tryp was also used in doses of 3 g daily successful (Lam et al. 1997). As a sleep aid, however, are already doses of ≥ 1 g sufficiently effective. The repeated administration of daily 1,5 - 3 g Tryp about 2 to 3 weeks seems sufficient to offset a relative lack of central serotonin and make positive changes happen (aan het Rot et al 2006).. A daily dose of 1.5 g Tryp is only sufficient when the conditions for admission are designed so that high concentrations of free Tryp effect at the blood-brain barrier for a sufficiently long period. The intake of eg 1.5 g Tryp together with a normal meal are not likely to increase the supply of free Tryp to the BH bound critical.
principle, the inclusion of Tryp together with protein-rich foods inappropriate influence on the central serotonin synthesis significantly. 3 g daily dose Tryp-sufficient only if the administration in the fasting state, ie,> 3 hours after the last and at least 2 hours before your next meal is - 1.5 are accordingly. Further optimized the concentration of free Tryp if the Tryp-taking after a long fasting period (the morning before the first meal) takes place. Under a long-lasting endurance exercise (eg running or cycling), without intermediate energy supply to be achieved almost perfect conditions to stimulate the inclusion of the CNS and the central serotonin synthesis (Chaouloff 1997).
principle, the inclusion of Tryp together with protein-rich foods inappropriate influence on the central serotonin synthesis significantly. 3 g daily dose Tryp-sufficient only if the administration in the fasting state, ie,> 3 hours after the last and at least 2 hours before your next meal is - 1.5 are accordingly. Further optimized the concentration of free Tryp if the Tryp-taking after a long fasting period (the morning before the first meal) takes place. Under a long-lasting endurance exercise (eg running or cycling), without intermediate energy supply to be achieved almost perfect conditions to stimulate the inclusion of the CNS and the central serotonin synthesis (Chaouloff 1997).
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