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The consequences of long-term tryptophan supplementation: Interactions between dopamine and tryptophan

Lists the long-term administration of tryptophan to a disturbance in dopamine metabolism?

As a result of a long-term use of Tryp with stimulation of central serotonin synthesis can lead to a relative lack of dopamine (Andrews et al. 1978 Hashiguti et al. 1993). This interaction is observed only after several months to years Tryp resource. Several studies suggest that serotonin and dopamine synthesis is regulated in dependence on each other (Trouvin et al. 1991). An increased synthesis of serotonin has an inhibitory effect on dopamine synthesis and vice versa (Hashiguti et al. 1993). The permanent stimulation of serotonin synthesis by the administration of tryptophan seems long to a reduced central dopamine activity result. The probatory administration of L-dopa can be considered for positive response as an indication of the existence of a relative lack of dopamine. To prevent this imbalance of dopamine and serotonin, it seems necessary at times to stimulate the central dopamine synthesis. There is evidence that can stimulate the synthesis of the neurotransmitter dopamine in a similar manner to serotonin by the administration of the precursor tyrosine (Acworth et al. 1988 Rasmussen et al. 1983, Benedict et al. In 1983, During et al. 1989). One way to compensate for this imbalance between serotonin and dopamine, is therefore in the gift of tyrosine in the revenue from the Tryp breaks in a dose of 20 mg / kg (Badawy et Williams 1982). This early functional dopamine deficiency may manifest in healthy individuals under long-term administration Tryp especially during exercise. When running benefit may show a deterioration in mileage, which is subjectively perceived as a kind of rigidity, as "tough running motion" in analogy to the "wächsenden" resistance in the context of Parkinson's disease. The movement does not seem so fluid, the rotor requires much more drive to get the same performance level. Under L-dopa administration (daily 100 mg + 25 mg carbidopa), this deficit improved within 5 to 7 days. It is striking that when corrected for the relative lack of dopamine observed increased strain readiness, improved motivation and a generally increased drive. Since influence the dopamine and serotonin synthesis each other if neither tyrosine nor L-dopa are administered with Tryp. Sequential administration, however, permits the correction of relative dopamine deficiency. prevent

To a disturbance in dopamine metabolism by the unilateral tryptophan, regular supplementation with Tyrosine is recommended. Treatment with L-dopa (with carbidopa) should the situation are reserved, at which the adjusted basis of a long-term unilateral stimulation of serotonin synthesis with Tryp a clinically apparent, relative lack of dopamine.

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